Folks have gotten Blue Iris to run in compatibility layers of some kind before but always with bugs and I believe also extra program crashes, which is no good.
WinBoat lets you run any Windows application on Linux with seamless desktop integration. Elegant interface, automated installs, filesystem integration, and native OS-level windows.
WinBoat looks like it should work fine, but it is just using a fairly standard virtual machine internally so you get the full overhead of a Windows installation. Apparently it uses Remote Desktop protocol somehow to load individual GUI apps from the Windows VM into the linux desktop environment. This means the GUI will not run at native speed. Expect some CPU overhead and possibly a little bit of input lag and poor frame rate. It is also unclear how seamless the clipboard interaction is or what kind of file I/O overhead you get when saving and reading video files.
Really the only reason id run Blue Iris in WinBoat (as opposed to a more standard Windows VM) is if I really, really wanted Blue Iris's local console to be on a linux desktop pretending to be a native app.
I agree that WinBoat looks like an interesting project that could simplify running (some) Windows apps under Linux (probably better than Wine), but yeah, running BI in there just sounds very likely to be slow. Too many layers of "box inside a box" virtualization for something that needs near realtime performance.
I expect it to perform about the same as if you had a traditional Windows VM and were just using Blue Iris's local console through Remote Desktop (which is a pretty common setup). That is essentially what WinBoat is doing, although apparently with some trickery to make it only send individual program windows through the Remote Desktop Protocol instead of the whole Windows desktop all of the time.